Fall 2025 Vaccine Guide: What To Know About Covid, Flu, And RSV Shots

Cooler air and golden leaves mark the return of respiratory virus season. The CDC expects similar levels of hospitalizations from COVID-19, flu, and RSV as last year, meaning it’s time to start thinking about prevention again.

While there’s no way to avoid every germ, vaccines remain one of the best tools for protection. Health officials say taking a few small steps now can go a long way toward staying healthy all winter long.

Why Getting Vaccinated Still Matters

Some people question whether vaccines are still worth it after catching the flu or COVID in the past. Doctors explain that vaccines don’t always prevent infection, but can help reduce the severity of illness, which keeps most people out of the hospital.

The CDC estimates that last season there were about one million flu hospitalizations and roughly 130,000 flu-related deaths. 

COVID-19 led to nearly 540,000 hospitalizations and as many as 63,000 deaths. Those numbers underline why annual shots still make sense, even if you’ve been vaccinated before.

COVID-19: What’s New This Year

This year’s COVID-19 vaccine has been updated to better target current variants and is available to everyone six months and older, including pregnant individuals. 

The CDC now recommends a shared decision-making approach, meaning people should discuss the timing and ther needs with their doctors.

Pfizer, Moderna, and Novavax all have approved vaccines on the market. Most major pharmacies and doctors’ offices are offering them again, and access has expanded nationwide without the need for prescriptions.

Experts suggest getting vaccinated in October or early November to be protected before the holidays. The shot is covered by most insurance plans and, without coverage, it costs around $220 at retail pharmacies.

Studies show last year’s vaccine reduced the risk of hospitalization by nearly 40% and lowered COVID-related deaths by more than 60%. It seems vaccines remain the most effective way to prevent severe illness, and health authorities note that it’s safe to receive your COVID and flu shots at the same time if you’d like.

The Flu: Still A Seasonal Must

The flu shot continues to be recommended for everyone six months and older, with a second dose needed for some young children who are being vaccinated for the first time.

September and October are, again, the best months to get the shot. Doctors often remind patients to aim for vaccination by Halloween, allowing enough time for children’s immunity to build before peak flu activity begins in late fall.

C\Healthcare coverage remains strong, with most insurance plans paying the full cost. Without coverage, prices range from about $30 for a standard dose to $130 for a high-dose version recommended for older adults. The CDC estimates last year’s vaccine prevented up to half of potential flu infections in adults.

This season also brings new convenience. The nasal spray, FluMist, which can be delivered to your home in most states, is an option for anyone who prefers to skip the needle. Adults under 50 can self-administer it, and parents can use it for children as young as two.

RSV: Expanding Protection

The RSV vaccine is now recommended for adults 75 and older and for those 50 to 74 with certain health conditions. One dose provides protection for at least two years, and experts recommend getting it in the late summer or early fall.

For parents, protection options extend to infants, as well. Pregnant women between 32 and 36 weeks can receive a vaccine that passes antibodies to the baby before birth, while newborns can receive an antibody shot shortly after delivery.

Most insurance plans cover the RSV vaccine but, without coverage, it costs around $350. Patient assistance programs may reduce the price if you’re paying out of pocket.

Simple Steps To Stay Healthy

Vaccines make the biggest difference, but good everyday habits still matter, too. Doctors continue to emphasize frequent handwashing, staying home when sick, and avoiding crowded indoor spaces when virus levels are high. Masks are optional, but can help protect those at higher risk.

Health experts also highlight the basics of a strong immune system: enough sleep, plenty of fruits and vegetables, and good hydration. They note that small, consistent habits often have a bigger impact than sudden health overhauls.

This fall and winter may bring another active respiratory virus season, but this year’s tools might make it easier to stay ahead of illness. Whether you’re updating your COVID-19 vaccine, getting your annual flu shot, or adding the RSV vaccine to your list, a little preparation now can mean a healthier, happier holiday season ahead.

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