Buffalo Bills 2025 Schedule Predictions: Game Picks and Key Matchups to Watch
With the NFL’s 2025 schedule release just around the corner, Bills fans are already getting restless. There’s plenty of hope in Buffalo these days. And plenty of pressure too.
Josh Allen is still the face of the franchise, and expectations haven’t cooled after last year’s playoff run. If anything, they’ve only grown louder. The window is still open, but the road ahead won’t be easy. That makes this upcoming schedule feel especially important.
While the full week-by-week breakdown will be revealed during the NFL schedule release, we already know who the Bills will face this fall. Based on 2024 standings and the NFL's rotating format, we can take a solid crack at predicting the Buffalo Bills' 2025 schedule, highlighting potential marquee matchups, tough stretches, and opportunities to rack up wins.
What We Know About the Buffalo Bills' 2025 Opponents
The Buffalo Bills 2025 schedule includes the usual six divisional games: two against the New England Patriots, Miami Dolphins, and New York Jets. But the non-divisional matchups add intrigue.
Here's a look at the Bills' 2025 opponents:
Home Games
Kansas City Chiefs
Houston Texans
Arizona Cardinals
Jacksonville Jaguars
New England Patriots
Miami Dolphins
New York Jets
NFC West TBD (based on 2024 standings)
Away Games
Baltimore Ravens
Indianapolis Colts
San Francisco 49ers
Los Angeles Rams
New England Patriots
Miami Dolphins
New York Jets
NFC South TBD (based on 2024 standings)
It's a balanced slate with elite quarterback duels, cross-conference tests, and must-win divisional games.
Game-By-Game Predictions and Picks
Let's break down the most anticipated matchups and how the Bills might fare:
Bills vs. Chiefs (Home)
This could be one of the biggest regular-season games of the year. With playoff revenge on the minds of Buffalo fans, a home clash with Patrick Mahomes could set the tone early in the schedule.
Prediction: Bills win a shootout in Orchard Park.
Bills at 49ers (Away)
One of the toughest road trips of the season. San Francisco's defense will challenge Allen, and the West Coast travel never helps.
Prediction: Close loss for Buffalo in a low-scoring grind.
Bills vs. Dolphins (Home and Away)
Expect these two games to help shape the AFC East race. If Buffalo can contain Tua Tagovailoa and limit the deep ball, they'll sweep the series.
Prediction: Bills split the season series.
Bills at Ravens (Away)
A classic cold-weather December game? Count on it. Allen vs. Lamar Jackson is a must-watch matchup.
Prediction: Bills pull off a gritty upset.
Season Outlook and Key Challenges
On paper, this 2025 NFL season looks manageable but far from easy. The Bills will face multiple playoff-caliber teams, including Kansas City, Baltimore, and San Francisco. The offensive line must step up against some of the league's best pass rushes, and the secondary will be tested by high-powered aerial attacks.
But the team's core remains intact. Allen continues to operate as one of the most dynamic quarterbacks in football. If the defense stays healthy, Buffalo should be in the thick of the AFC playoff picture once again.
What to Watch for in the Official NFL Schedule Release
When the schedule comes out, a few things will matter more than others. The bye-week is one of them. If it lands around midseason, great. If it’s too early or too late, that could hurt, especially with how banged-up this team has gotten down the stretch in recent years.
Then there’s the December travel. A couple of late-season road games in tough weather could end up deciding where the Bills land in the playoff picture.
And keep your ear to the ground because there is still talk about a possible London game. Nothing is official yet. But if that happens, it will most undoubtedly throw a wrench into the rhythm of the season.
Closing Take
The Buffalo Bills remain stacked with talent as we enter the 2025 season, and the expectation is clear: compete deep into January, maybe even February. But as always, the path will be tough.
There are questions about depth, about how they'll hold up during the grind, and whether this group can finally get over the postseason hump. If the Bills stay healthy and take care of business in key matchups, they’ve got every chance to make this year count.
All eyes now turn to the NFL schedule release, where the timing of these matchups will tell us even more about the road ahead.