Kit KittlestadAug 11, 2025 4 min read

Vitamins You Should Never Take With Coffee

Vitamins and supplements in pill form and a cup of coffee.
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If you’re someone who washes down your vitamins with your first cup of coffee, it might be time to rethink the routine. 

While coffee is packed with antioxidants and can be part of a healthy diet, certain combinations of vitamins and coffee can keep your body from getting the full benefits of those supplements. 

The problem comes down to timing, and knowing which nutrients don’t play nicely with caffeine.

Can Coffee Cancel Out Your Vitamins?

Some compounds in coffee, like polyphenols and tannins, can interfere with vitamin absorption. Caffeine itself can have a diuretic effect, meaning you might excrete certain vitamins before your body gets a chance to use them. 

Pill with coffee beans.
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But, the fix is simple: understand the key caffeine interactions and adjust your supplement schedule to make sure your morning brew isn’t creating common vitamin mistakes.

Iron and Coffee: A Risky Pair

Iron is one of the most sensitive nutrients when it comes to supplements and caffeine. The polyphenols and tannins in coffee bind to iron in your digestive tract, making it harder for your body to absorb. 

In fact, one study found that taking iron with coffee reduced absorption by more than half compared to taking it with water.

If you’re already prone to low iron levels, this is especially important. Low iron can leave you feeling tired, weak, and sluggish. 

To protect your iron intake, try having coffee at least an hour before or after taking your iron supplement. 

You can also boost absorption by pairing iron-rich foods with a source of vitamin C, like spinach with strawberries, or lentils with a squeeze of lemon.

The B Vitamin Problem

Woman drinking coffee.
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B vitamins are water-soluble, which means your body doesn’t store them for long. Caffeine’s diuretic effect can speed up how quickly these vitamins exit your system. 

That means if you take your B complex with coffee, you might be losing some of the benefits before your body gets a chance to fully absorb them.

Since B vitamins are crucial for energy production, mood support, and healthy brain function, you want them to stick around. 

If you’re taking a supplement, consider moving it to later in the morning or even the afternoon when you’re less likely to be sipping coffee. That way, you’ll still get your caffeine and vitamins fix, but your body will have a better shot at using every bit of those nutrients.

Calcium’s Indirect Coffee Connection

Coffee doesn’t just interact with calcium directly. It can also affect the vitamin D your body needs to absorb calcium effectively. 

Lower vitamin D levels mean you may not get the full benefit of the calcium you consume, whether from supplements or food. Over time, this could have an impact on bone health, particularly if you’re at higher risk for osteoporosis.

Cappuccino in the sun.
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To keep your bones strong, avoid taking calcium supplements right alongside your coffee. Instead, take them with a meal later in the day, ideally with a source of healthy fat to help with absorption. 

That way, your morning latte doesn’t unintentionally weaken your bones’ support system.

Tips for Better Vitamin Absorption

If you want to enjoy coffee and supplements, timing is everything. Here are a few simple strategies:

  • Space It Out: Wait at least an hour after drinking coffee before taking supplements like iron, calcium, or B vitamins.

  • Switch Up Your Routine: Consider taking coffee-friendly vitamins in the morning and moving others to lunch or dinner.

  • Stay Hydrated: Since caffeine can have a diuretic effect, drink plenty of water throughout the day to help your body hold onto water-soluble vitamins.

  • Check Your Labels: Some multivitamins contain a mix of nutrients that may be affected by coffee. If that’s the case, adjust your coffee time accordingly.

The Last Sip on Vitamins and Coffee

Your morning coffee doesn’t have to be the enemy of good nutrition. You just need to prevent the two from clashing. 

By understanding vitamins and caffeine interactions, and by giving your supplements their own time to shine, you’ll get the best of both worlds: the energy and enjoyment of your favorite brew, as well as the full benefits of the nutrients your body needs.

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